Immunological reactivity in patients with unstable angina pectoris

1Zavalskaya, TV
1O.O. Bogomolets National Medical University, Kyiv
Dopov. Nac. akad. nauk Ukr. 2014, 4:168-171
https://doi.org/10.15407/dopovidi2014.04.168
Section: Medicine
Language: Ukrainian
Abstract: 

The study involved 67 patients with unstable angina pectoris (UAP) aged 55 to 69 years (20 patients with recent onset angina pectoris and 47 patients with progressive angina pectoris) and 22 healthy individuals. Determination of population and subpopulation of lymphocytes was performed by monoclonal antibodies. Determination of immunoglobulins Ig G, Ig A, Ig M, and circulating immune complexes (CIC) in blood serum was performed by the Mancini method. The results showed that immunological changes of patients with UAP manifest by depression of T-cell immunity with the development of T lymphocytes subpopulations imbalance (predominant T-suppressor reduction). UAP patients had humoral immunity activation indicated by an increase of the CIC and Ig G.

Keywords: immunological reactivity, unstable angina pectoris
References: 

1. Hansson G. K., Libby P., Schonbeck U., Yan Z. Q. Circ. Res., 2002, 91: 281–291. https://doi.org/10.1161/01.RES.0000029784.15893.10
2. Babov K. D., Shumakov V. A., Bratus V. V. Ukr. kardiol. zhurn., 1995, No. 2: 17–21 (in Russian).
3. Shumakov V. A. Ukr. kardiol. zhurn., 2007, No. 5: 48-54 (in Russian)– 2007.
4. Atchley D. H., Lopes-Virella M. F., Zheng D. et al. Diabetologia, 2002, 45: 1562–1571. https://doi.org/10.1007/s00125-002-0962-y
5. Caligiuri G., Nicoletti A., Poirier B., Hansson G. K. J. Clin. Invest., 2002, 109: 745–753. https://doi.org/10.1172/JCI7272
6. Horkko S., Binder C. J., Shaw P. X. et al. Free Radic. Biol. Med., 2000, 28: 1771–1779. https://doi.org/10.1016/S0891-5849(00)00333-6
7. Gratsiansky N. A. Kardioilogiia, 2002, 42, No. 1: 4-14 (in Russian).
8. Kazimirchuk V. E. Vnutrenniaia meditsina, 2007, 4(4): 13–18 (in Russian).
9. Kitaev M. I., Beishenkulov M. T., Baitelieva A. A., Davletova Ch. I. Kardioilogiia, 2007, 47, No. 3: 25–27 (in Russian).
10. Peremot S. D., Tseluiko V. I., Smelyanskaya M. V. et al. Ukr. kardiol. zhurn., 2000, No. 3: 30-33 (in Russian).
11. Emerson E., Robertson A. Amer. J. Pathol., 1988, 130, No. 2: 369–376.
12. Song L., Leung C., Schindler C. J. Clin. Invest., 2001, 108: 251–259. https://doi.org/10.1172/JCI200111380
13. Stemme S., Rymo L., Hansson G. K. Lab. Invest., 1991, 65, No. 6: 654–660.
14. Stokes K. Y., Clanton E. C., Bowles K. S. et al. Microcirculation, 2002, No. 9: 407–417. https://doi.org/10.1038/sj.mn.7800148