Effect of the complex of C60 fullerene with doxorubicin on tumor cells in vitro and in vivo

1Prylutska, SV
1Taras Shevchenko National University of Kyiv
Dopov. Nac. akad. nauk Ukr. 2014, 6:146-150
https://doi.org/10.15407/dopovidi2014.06.146
Section: Biochemistry
Language: Ukrainian
Abstract: 

A technological scheme for preparing a stable aqueous solution of C60 fullerene with an antibiotic doxorubicin (Dox) of the anthracycline row is proposed. The toxic effect of the C60+Dox complex on cells of Ehrlich ascites carcinoma, leukemia L1210, and Lewis lung carcinoma is demonstrated. Its antitumor effect on Lewis lung carcinoma in vivo was also shown. Thus, a high efficiency of the C60+Dox complex in the anticancer therapy is postulated.

Keywords: complex of C60 fullerene, doxorubicin, tumor cells
References: 

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