|1Danylov, MO, 1Ostrovska, GV, 1Rybalchenko, VK |
1ESC "Institute of Biology", Taras Shevchenko National University of Kyiv
|Dopov. Nac. akad. nauk Ukr. 2014, 7:140-144|
The maleimide derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione causes no destructive effect on the histological structure in rat's liver after the 7 week administation. It also has a partial protective effect under the conditions of colon carcinogenesis, induced by 1,2-dimethylhydrazine, unlike traditional anticancer drug 5-fluorouracil, which showed hepatotoxic effects.
|Keywords: 5-fluorouracil, colon carcinogenesis, maleimide, rat's liver|
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