Title | α,α-Difluoro-β-ketophosphonates on a tetraazamacrocyclic platform: Synthesis and inhibitory activity against protein tyrosine phosphatases |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Khavrienko, DI, Kobzar, OL, Shevchuk, MV, Romanenko, VD, Kobelev, SM, Averin, AD, Beletskaya, IP, Vovk, AI, Kukhar, VP |
Abbreviated Key Title | Dopov. Nac. akad. nauk Ukr. |
DOI | 10.15407/dopovidi2014.09.109 |
Issue | 9 |
Section | Chemistry |
Pagination | 109-115 |
Date Published | 9/2014 |
Language | English |
Abstract | The present study offers a new approach for designing inhibitors of protein tyrosine phosphatases. We have synthesized the cyclam derivatives with α,α-difluoro-β-ketophosphonate fragments covalently attached to tetraazamacrocyclic scaffold, which is known to be of medical interest. The obtained functionalized macrocycles were evaluated as inhibitors of PTP1B, TC-PTP, CD45, and other protein tyrosine phosphatases. |
Keywords | inhibitory activity, phosphatases, synthesis, α;α-Difluoro-β-ketophosphonates |
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