Synthesis of composite materials based on oligooxypropylene fumarate, triethylene glycol dimethacrylate, and styrene with prolonged release of levamisole

1Rudenchyk, TV
1Rozhnova, RA
1Galatenko, NA
1Nechaeva, LYu.
1Kiselova, TO
1Institute of Macromolecular Chemistry of the NAS of Ukraine, Kyiv
Dopov. Nac. akad. nauk Ukr. 2016, 11:78-86
https://doi.org/10.15407/dopovidi2016.11.078
Section: Chemistry
Language: Ukrainian
Abstract: 

Composite materials with levamisole based on oligooxypropylene fumarate, triethylene glycol dimethacrylate, and styrene are synthesized. The influence of the polystyrene component on the structure and physical-mechanical properties of the obtained polymeric materials is established. The dynamics of release of levamisole from a polymer matrix of composite materials is investigated by the method of spectrophotometry. It is established that the ternary composites with styrene are characterized by a full prolonged release of levamisole.

Keywords: composite materials, dynamics of release, levamisole, oligooxypropylene fumarate, styrene
References: 
  1. Makarov K. A., Kibardin S. A. The immobilized biological preparations in medicine, Moscow: Meditsina, 1980 (in Russian).
  2. Bondarenko P. A., Rudenchyk T. V., Rozhnova R. A., Galatenko N. A. Plasticheskiye massy, 2012, No 12: 35—38 (in Russian).
  3. Pat. 6753358 US, A61L 27/00, A61L 27/18, C08L 67/06, C08L 67/00, C08F 002/50, C08F 022/00. Photocrosslinking of diethyl fumarate/poly(propylene fumarate) biomaterials, J. P. Fisher, A. G. Mikos, applicant and patentee William Marsh Rice University, No 10/185,473; filed 28.06.2002; publ. 22.06.2004.
  4. Fisher J. P., Dean D., Mikos A. G. Biomaterials, 2002, 23, No 22: 4333-4343. doi: https://doi.org/10.1016/S0142-9612(02)00178-3
  5. Temenoff J. S., Kasper F. K., Mikos A. G. Topics in Tissue Engineering, Eds. N. Ashammakhi, R. L. Reis, E. Chiellini, Oulu, 2007, Vol. 3, Ch. 5.
  6. Peter S. J., Kim P., Yasko A. W., Yaszemski M. J., Mikos A. G. J. Biomed. Mater. Res., 1999, 44, No 3: 314-321. doi: https://doi.org/10.1002/(SICI)1097-4636(19990305)44:3<314::AID-JBM10>3.0.CO;2-W
  7. Hacker M. C., Haesslein A., Ueda H., Foster W. J., Garcia C. A., Ammon D. M., Borazjani R. N., Kunzler J. F., Salamone J. C., Mikos A. G. J. Biomed. Mater. Res. Pt. A, 2009, 88 A, No 4: 976-989.
  8. Rudenchyk T. V., Rozhnova R. A., Galatenko N. A., Kiselova T. O. Magisterium, 2016, No 63: 35-40 (in Ukrainian).
  9. Galatenko N. A., Nechaeva L. Yu., Khranovskiy V. A. Dokl. AN Ukrainy, 1994, No 9: 143-147 (in Russian).
  10. Pkhakadze G. A., Tereshchenko L. T., Galatenko N. A., Kolomiytsev A. K. Biosovmestimost, 1993, 1, No 1: 33-41 (in Russian).
  11. GOST 23206-78. Rigid cellular plastics. Compression test method, Moscow: Izd-vo standartov, 1978 (in Russian).
  12. Bellamy L. The infra-red spectra of complex molecules, Moscow: Izd-vo inostrannoy literatury, 1963 (in Russian).
  13. Korenman I. M. Extraction in the analysis of organic substances, Moscow: Himiya, 1977 (in Russian).
  14. Nechaeva L. Yu., Galatenko N. A., Bufius N. N. Farmatsiya, 1989, No 2: 24—27 (in Russian).
  15. Rudenchyk T. V., Rozhnova R. A., Galatenko N. A., Nechaeva L. Yu., Kiselova T. O. Naukovi zapysky NaUKMa, 2015, 170: 53—58 (in Ukrainian).