Title | Regulatory effect of vitamin D3 on proinflammatory processes in liver of diabetic mice |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Labudzynskyi, DO, Kubaichuk, KI, Shymanskyi, IO, Veliky, MM |
Abbreviated Key Title | Dopov. Nac. akad. nauk Ukr. |
DOI | 10.15407/dopovidi2016.06.127 |
Issue | 6 |
Section | Biochemistry |
Pagination | 127-132 |
Date Published | 6/2016 |
Language | Ukrainian |
Abstract | It is shown that the induction of pluripotent proinflammatory interleukin 6 (IL-6) in liver in diabetes is accompanied by increased expression of osteopontin (OPN) — molecular regulator of the synthesis of proinflammatory cytokines. Changes in the OPN and IL-6 expression correlate with a significant deficiency of vitamin D3 in organism. Normalization of the vitamin D3 level leads to a substantial reduction of the expression level of both OPN and IL-6 mRNA, showing the cytoprotective effect of cholecalciferol in diabetes-induced liver disorders. |
Keywords | cytokines, diabetes mellitus, vitamin D3 |
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