Optimization of targeted drug delivery from systems of microneedles

TitleOptimization of targeted drug delivery from systems of microneedles
Publication TypeJournal Article
Year of Publication2017
AuthorsLyashko, SI, Klyushin, DA, Onotskyi, VV, Bondar, OS
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
SectionInformation Science and Cybernetics
Date Published11/2017

We consider the simulation and optimization problem of transdermal drug transport from systems of solvable microneedles. We solve a one-dimensional problem of vertical transport of drugs through the porous media with point sources simulating solvable microneedles. Controlling the intensity and setting coordinates of the sources, we solved the problem of optimal control over the transdermal drug transport and achieved a desired distribution of drugs in epidermis with acceptable precision. To solve the boundary-initial problems, we use finite-difference methods and two-step symmetrizable algorithm.

Keywordsdifference scheme, microneedle system, optimization, point source, simulation, transdermal diffusion
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