Optimization of targeted drug delivery from systems of microneedles

1Lyashko, SI, Klyushin, DA, Onotskyi, VV, Bondar, OS
1Taras Shevchenko National University of Kyiv
Dopov. Nac. akad. nauk Ukr. 2017, 11:16-23
https://doi.org/10.15407/dopovidi2017.11.016
Section: Information Science and Cybernetics
Language: Ukrainian
Abstract: 

We consider the simulation and optimization problem of transdermal drug transport from systems of solvable microneedles. We solve a one-dimensional problem of vertical transport of drugs through the porous media with point sources simulating solvable microneedles. Controlling the intensity and setting coordinates of the sources, we solved the problem of optimal control over the transdermal drug transport and achieved a desired distribution of drugs in epidermis with acceptable precision. To solve the boundary-initial problems, we use finite-difference methods and two-step symmetrizable algorithm.

Keywords: difference scheme, microneedle system, optimization, point source, simulation, transdermal diffusion
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