Effects of milk thistle and flaxseed oils obtained by the methods of cold and hot pressings on the state of colon under acute colitis in rats

TitleEffects of milk thistle and flaxseed oils obtained by the methods of cold and hot pressings on the state of colon under acute colitis in rats
Publication TypeJournal Article
Year of Publication2017
AuthorsKuznietsova, HM, Denis, EO, Moskalets, TZ, Rybalchenko, VK
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2017.03.085
Issue3
SectionBiology
Pagination85-91
Date Published3/2017
LanguageUkrainian
Abstract

The effects of consumption of cold-pressed (43—45 ºC) and hot-pressed (95 ºC) flaxseed and milk thistle oils on the development of acute colitis in rats are investigated. It is shown that cold- and hot-pressed flaxseed and hotpressed milk thistle oils significantly prevent the development of inflammatory, destructive, and degenerative changes in colon mucosa. These oil properties could be realized partially by unsaturated fatty acids, in particular ω3, including minor ones.
Keywordsacute colitis, flaxseed oil, milk thistle oil
References: 
  1. Lakatos, P. L. (2006). Recent trends in the epidemiology of inflammatory bowel diseases: up or down. World J. Gastroenterol., 12, No. 38, pp. 6102-6108. https://doi.org/10.3748/wjg.v12.i38.6102
  2. Feuerstein, J. D. & Cheifetz, A. S. (2014). Ulcerative colitis: epidemiology, diagnosis, and management. Mayo Clin. Proc., 89, No. 11, pp. 1553-1563. https://doi.org/10.1016/j.mayocp.2014.07.002
  3. Amani, S. A., Reham, M. M. & Gamal, A. S. (2013). Natural products in treatment of ulcerative colitis and peptic ulcer. J. Saudi Chem. Soc., 17, pp. 101-124. https://doi.org/10.1016/j.jscs.2012.03.002
  4. Calder, P. C. (2010). Omega-3 Fatty Acids and Inflammatory Processes. Nutrients, 2, pp. 355-374. https://doi.org/10.3390/nu2030355
  5. Verma, N. & Paul, J. (2014). Silibinin ameliorates Dextran Sodium Salt induced colitis in mice and prevents overexpression of inflammatory genes in lipopolysaccharide activated human macrophages. Inflammation and cell signaling, 1, e117.
  6. Kurambaev, S. R., Achilova, S. S., Baizhanov, N. I., Karimova, D. Z., & Sobirova, R. N. (2016). Obtaining melon oil from "Khorezm Bishak" melon seeds using the method of cold pressing. Molodoi uchenyi, 112, No. 8, pp. 253-254 (in Russian).
  7. Fitzpatrick, L. K., Bostwik, J. S. & Renzetti, M. (1990). Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. Agents Actions, 30, pp. P393-P403. https://doi.org/10.1007/BF01966304
  8. Sehirli, A., Tatlydede, E., Yuksel, M., Erzik, C., Cetinel, S., Yegen, B. C. & Sener, G. (2009). Effects of Alpha-Lipoic Acid Against Oxidative Injuri in TNBS-induced Colitis. Erciyes Med. J., 31, No. 1, pp. 15-26.
  9. Appleyard, C. & Wallace, J. (1995). Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs. Am. J. Physiol., 269, pp. G119-G125.
  10. Benoit, B., Bruno, J., Kayal, F., Estienne, M., Debard, C., Ducroc, R. & Plaisancie, P. (2015). Saturated and Unsaturated Fatty Acids Differently Modulate Colonic Goblet Cell In Vitro and in Rat Pups. J. Nutr., 145, pp. 1754-1762. https://doi.org/10.3945/jn.115.211441
  11. Chen, S. J., Chuang, L. T. & Chen, S. N. (2015). Incorporation of eicosatrienoic acid exert mild anti-inflammatory properties in murine RAW264.7 cells. Inflammation., 38, No. 2, pp. 534-545. https://doi.org/10.1007/s10753-014-9960-8