The lack of modifying effect of astaxanthin on cytogenetic effects in irradiated in vitro human peripheral blood lymphocytes on stage G2 of the cell cycle

1Kurinnyi, DA
2Rushkovsky, SR
1Pilinska, MA
1National Research Center for Radiation Medicine of the NAMS of Ukraine, Kyiv
2Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv
Dopov. Nac. akad. nauk Ukr. 2017, 4:91-95
Section: Genetics
Language: Ukrainian

Radioprotective potential of astaxanthin after gamma-irradiation of human peripheral blood lymphocytes' cultures in vitro in dose 1.0 Gy on the post synthetic (G2) stage of the first mitotic cycle has been studied. The lack of astaxanthin modifying effect on stage G2 has been demonstrated. No significant changes in the total frequency of chromosomal disorders and in the spectrum of chromosomal aberrations are detected. The comparison of astaxanthin effects between stage G2 and G0 of the cell cycle is conducted.

Keywords: astaxanthin, chromosome aberrations, culture of human peripheral blood lymphocytes, radioprotective effect
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