|1Boshytska, NV |
1I. M. Frantsevich Institute for Problems of Materials Sciences of the NAS of Ukraine, Kyiv
|Dopov. Nac. akad. nauk Ukr. 2017, 8:43-50|
|Section: Materials Science|
Interaction of composite systems on the bases of hydroxyapatite and polyethylene glycol (HAP + PEG) with molecular weights of 400 and 6000 with physiological Ringer and Ringer-Locke solution of NaCl has been investigated. By the methods of chemical analysis, it is established that the HAP + PEG 400 composite system interacts with biological media liberating calcium from a material step-by-step. The powder HAP + PEG 6000 system remains chemically stable during 100 h. By IR-spectroscopy, it is demonstrated that the spectrogram of surfaces of HAP + PEG 400 and HAP + PEG 6000 samples after the interaction with physiological solutions during 100 h contains valence vibrations in a range corresponding to the PEG presence. It can be supposed that the chemical activity of HAP + PEG 400 material relative to calcium and the prolonged presence of polyethylene glycol in the biological media help a reduction in both mineral metabolism and nervous impulses at bone defects. It is shown that the composite HAP + PEG 400 system is promising for the future development of materials for orthopedic applications.
|Keywords: chemical stability, hydroxyapatite, physiological solution, polyethylene glycol, surface|
- Delgado, C., Francis, G. & Fisher, D. (1992). The Uses and Properties of PEG-Linked Proteins. Crit. Rev. Ther. Drug Carrier Syst., 9 (3/4), pp. 249-304.
- Bruce, A. (2001). Clinical considerations in pegylated protein therapy. From Research to Practice, 3 (1), pp. 3-9.
- Batiza, R. & White, J. D. L. (1999). Submarine Lavas and Hyaloclastite. Encyclopedia of Volcanoes; 1417 p. Ed. H. Sigurdsson. New York: Academic Press.
- Garratty, G. (2008). Modulating the Red Cell Membrane to Produce Universal/Stealth Donor Red Cells Suitable for Transfusion. Vox Sanguinis, 94, No. 2, pp. 87-95.
- Pertsiv, I.M, Datsenko, B. M, Gunko, V. Y. (1991). Development of drugs multidirectional action on purulent inflammation: study of manufacturing, clinical experience and application. Pha. Zh., No. 3, pp. 5; 56-61; 65-68 (in Ukrainian).
- Jaiswal, J., Gupta, S. K. & Kreuter, J. (2004). Preparation of Biodegradable Cyclosporine Nanoparticles by High-Pressure Emulsion-Solvent Evaporation Process. J. Control. Release, No. 96, pp. 169-178. https://doi.org/10.1016/j.jconrel.2004.01.017
- Bittner, G. D. et al. (2012). Rapid, Effective, and Long-Lasting Behavioral Recovery Produced by Micro sutures, Methylene Blue, and Polyethylene Glycol after Completely Cutting Rat Sciatic Nerves. J. Neuroscience Research, 90 (5), pp. 967-980. https://doi.org/10.1002/jnr.23023
- Bittner, G. D. et al. (2005). Melatonin Enhances the in vitro and in vivo Repair of Severed Rat Sciatic Axons. Neuroscience Letters, 376 (2), pp. 98-101. https://doi.org/10.1016/j.neulet.2004.11.033
- Britt, J. M., Kane, J. R., Spaeth, C. S. et al. (2010). Polyethylene Glycol Rapidly Restores Axonal Integrity and Improves the Rate of Motor Behavior Recovery after Sciatic Nerve Crush Injury. J. Neurophysiology, 104 (2), pp. 695-703. https://doi.org/10.1152/jn.01051.2009
- Sexton, K. W., Pollins, A. C., Cardwell, N. L. et al. (2012). Polyethylene Glycol Rapidly Restores Axonal Integrity and Improves the Rate of Motor Behavior Recovery after Sciatic Nerve Crush Injury. J. Surgical Research, 177 (2), pp. 392-400. https://doi.org/10.1016/j.jss.2012.03.049
- Pentin, Yu. A. & Vilkov, L. (1987). Physical methods of research in chemistry. Moscow: Higher School (in Russian).
- Liopo, V. A., Himpel, N. N. & Vasyl'yev, Ye. K. (1995). X-ray phase analysis using a database. X-ray application in science and technology.Irkutsk. State. Univ., pp. 125-131 (in Russian).
- Krylov, A. A, Kats, A. M and others. (1981). Manual for clinical diagnostic laboratories. Leningrad: Medicine (in Russian).