Inhibition of hemagglutinin-glycan interaction by complexes of oligoribonucleotides with D-mannitol

Melnichuk, NS, 1Tkachuk, ZYu.
1Institute of Molecular Biology and Genetics of the NAS of Ukraine, Kyiv
Dopov. Nac. akad. nauk Ukr. 2018, 1:92-99
https://doi.org/10.15407/dopovidi2018.01.092
Section: Biology
Language: Ukrainian
Abstract: 

By the results of the indirect determination of the amount of influenza virus titer by the hemagglutination assay, it is found that oligoribonucleotides-D-mannitol (ORNs-D-M) complexes interfere with HA–glycan interactions. The infectivity of influenza virus H1N1 (A/FM/1/47) decreases after the incubation with ORNs-D-M. It is shown that ORNs-D-M possess a direct virucidal action.

Keywords: hemagglutinin, influenza virus, oligoribonucleotides-D-mannitol complexes
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