Evaluation of the effect of professional irradiation on cytogenetic parameters of peripheral blood lymphocytes

1Domina, EA
1R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kyiv
Dopov. Nac. akad. nauk Ukr. 2018, 10:112-119
https://doi.org/10.15407/dopovidi2018.10.112
Section: Medicine
Language: Russian
Abstract: 

The cytogenetic examination of radiologists with different work experiences in the field of ioni zing radiation has been performed. Preliminary data indicate that radiologists with over 1.5 years of experience exhibit, ~ in 70 % of cases, an increased level of chromosomal aberrations, including dicentrics and translocations (from 0.5 to 6.0 / 100 metaphases). This indicates a radiation load on the genome of the examined professionals. The radiomitigators inosine and thymalin reduce the frequency of radiation-induced aberrations of chromosomes upon the irradiation in small doses to the values of the average population spontaneous level.

Keywords: blood lymphocytes, carcinogenic risk, genome instability, professional exposure, ra diomitigators
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