Correction of rat acute cholangitis using water-soluble C60 fullerene nanoparticles

1Kuznietsova, HM, 1Dziubenko, NV, 1Rybalchenko, TV, 1Ogloblya, OV, 1Rybalchenko, VK
1ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv
Dopov. Nac. akad. nauk Ukr. 2018, 2:102-108
Section: Biology
Language: Ukrainian

The effects of water-soluble biocompatible C60 fullerenes (C60FAS) when applied intraperitoneally or per os on the liver function under rat α-naphthyl-isothiocyanate-induced cholangitis model are investigated. C60FAS when administered per os normalizes the direct bilirubin and ALT. Additionally, total bilirubin and ALP are normalized under C60FAS intraperitoneal injection, by indicating the attenuation of disease symptoms severity. Thus, the partial correction of cholangitis-induced liver failure caused by C60FAS is demonstrated, and the higher efficacy of C60FAS intraperitoneal injection is concluded.

Keywords: C60 fullerenes, cholangitis
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