Synthesis of hetarylsubstituted pyrazolo[3,4-c] isoquinolines under Pictet—Spengler reaction conditions

1Bogdan, NM, 1Borodkin, Ya.S, 1Sujkov, SYu., 1Khairulin, AR, 2Bogza, SL
1Institute of Organic Chemistry of the NAS of Ukraine, Kyiv
2L. M. Litvinenko Institute of Physical-Organic and Coal Chemistry of the NAS of Ukraine, Kyiv
Dopov. Nac. akad. nauk Ukr. 2018, 4:81-87
https://doi.org/10.15407/dopovidi2018.04.081
Section: Chemistry
Language: Russian
Abstract: 

The synthesis and reactions of 1 and 3-hetaryl-substituted 5-aminopyrazoles with aldehydes under the Pictet—Spengler reaction conditions have been studied. It has been shown that the possibility of formation and yields of pyrazolo [3,4-c] isoquinoline derivatives essentially depends on the structure and location of the heterocyclic substituent in the pyrazole core.

Keywords: 5-aminopyrazoles, anticancer compounds, benzothiazole, Pictet—Spengler reaction, pyrazolo[3;4-c] isoquinolines, pyridine, pyrimidine
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