Physicochemical stability of powder on the basis of a detonation nanodiamond in physiological solutions

1Boshitska, NV, 1Protsenko, LS, 1Budilina, OM, 1Gogotsi, EG, 1Sinitsa, AO, 1Lesin, VG, 1Uvarova, IV
1I. M. Frantsevich Institute for Problems of Materials Sciences of the NAS of Ukraine, Kyiv
Dopov. Nac. akad. nauk Ukr. 2018, 4:54-59
https://doi.org/10.15407/dopovidi2018.04.054
Section: Materials Science
Language: Ukrainian
Abstract: 

Physicochemical stability of a detonation nanodiamondbased powder in physiological solutions with different chemical compositions such as NaCl, Ringer, Ringer–Locke, as well as water, have been investigated. By infrared spectroscopy, it is proved that, under the interaction of a nanodiamond powder with physiological solutions, the enrichment of the powder surface by oxygen-containing groups, which determine cation-exchange properties and characterize the processes of interaction of surface functional groups with biological media with the formation of secondary structures, takes place. The results make it possible to recommend a nanodiamond based powder for the following investigations as a stable foundation for the creation of drug suspensions with durable action.

Keywords: biological media, carbon, detonation nanodiamond
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