|1Boshitska, NV, 1Protsenko, LS, 1Budilina, OM, 1Gogotsi, EG, 1Sinitsa, AO, 1Lesin, VG, 1Uvarova, IV |
1I. M. Frantsevich Institute for Problems of Materials Sciences of the NAS of Ukraine, Kyiv
|Dopov. Nac. akad. nauk Ukr. 2018, 4:54-59|
|Section: Materials Science|
Physicochemical stability of a detonation nanodiamondbased powder in physiological solutions with different chemical compositions such as NaCl, Ringer, Ringer–Locke, as well as water, have been investigated. By infrared spectroscopy, it is proved that, under the interaction of a nanodiamond powder with physiological solutions, the enrichment of the powder surface by oxygen-containing groups, which determine cation-exchange properties and characterize the processes of interaction of surface functional groups with biological media with the formation of secondary structures, takes place. The results make it possible to recommend a nanodiamond based powder for the following investigations as a stable foundation for the creation of drug suspensions with durable action.
|Keywords: biological media, carbon, detonation nanodiamond|
- Dolmatov, V. Yu. (2001). Detonation synthesis of ultradispersed diamonds: properties and application. Russ. Chem. Rev., 70, No. 7, pp. 607-626. doi: https://doi.org/10.1070/RC2001v070n07ABEH000665
- Danilenko, V. V. (2003). Synthesis of diamonds an explosion. Moscow: Energoizdat (in Russian).
- Schrand, A. M., Ciftan Hens, S. A. & Shenderova, O. A. (2009). Nanodiamond particles: properties and perspectives for bioapplications. Crit. Rev. Solid State Mat. Sci., 34, Iss. 1-2, pp. 18-74. doi: https://doi.org/10.1080/10408430902831987
- Chekman, I.S. & Priskoka, A. O. (2010). Nanotechnologies in development of drug delivery systems. Ukrainskyi medychnyi chasopys, No. 1, pp. 34-41 (in Ukrainian).
- Nachalnaia, T. A., Maloholovets, V. H., Podziarei, H. A., Yvakhnenko, S. A., Zanevskyi, O. A., Ostrovskaia, L. Iu. & Ralchenko, V. H. (2000). EPR- and IR-spectroscopy of synthetic diamonds, similar in nature to natural diamonds of types Ia è IIa. Sverhtverdyie materialyi, No. 6, pp. 57-64 (in Russian).
- GOST 26239.7–84. Semiconductor silicon. Method of oxygen, carbon and nitrogen determination. Moscow, 1986 (in Russian).
- Goss, J. P., Coomer, B. J., Jones, R., Fall, C. J., Briddon, P. R. & Öberg, S. (2003). Extended defects in diamond: the interstitial platelet. Phys. Rev. B, 67, Iss. 16, 165208. doi: https://doi.org/10.1103/PhysRevB.67.165208
- Dischler, B. (2012). Handbook of spectral lines in diamond. Vol. 1. Tables and interpretations. Berlin: Springer. doi: https://doi.org/10.1007/978-3-642-22215-3
- Nefedov, Yu. V. (2014). Regularities in the manifestation of nitrogen defects in Ural-type diamond crystals (Unpublished candidate thesis). Saint Petersburg Mining University, St. Petersburg, Russian Federation (in Russian).
- Shenderova, O. A., Vlasov, I. I., Turner, S., Van Tendeloo, G., Orlinskii, S. B., Shiryaev, A. A., Khomich, A. A., Sulyanov, S. N., Jelezko, F. & Wrachtrup, J. (2011). Nitrogen control in nanodiamond produced by detonation shock wave-assisted synthesis. J. Phys. Chem. C, 115, pp. 14014-14024. doi: https://doi.org/10.1021/jp202057q
- Volkov, D. S. (2015). Complex approaches to the characterization of nanodiamonds of detonation synthesis and their colloidal solutions. (Unpublished candidate thesis). Lomonosov Moscow State University, Moscow, Russian Federation (in Russian).