Hepatoprotective effect of protein kinase inhibitor 1-(4-Cl-benzyl)-3-chloro-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione on rats' acute cholangitis

1Kuznietsova, HM
1Dziubenko, NV
1Lynchak, OV
1Tykhoniuk, OI
1Milokhov, DS
1Khilya, OV
1Rybalchenko, VK
1ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv
Dopov. Nac. akad. nauk Ukr. 2018, 5:83-90
Section: Biology
Language: Ukrainian

The effect of protein kinase inhibitor 1-(4-Cl-benzyl)-3-chloro-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione (MI-1) on liver states of rats experienced α-naphthyl isothiocyanate-induced acute cholangitis in comparison with an tiinflammatory drug prednisolone is investigated. Both prednisolone and MI-1 attenuated cholangitis manifestations and partially restored the liver functional activity: prednisolone decreased serum transaminases acti vities, while MI-1 leveled direct and total bilirubin, which could indicate its effectiveness for correcting the investigated pathology.

Keywords: 1-(4-Cl-benzyl)-3-chloro-4-CF3-phenylamino)-1H-pyrrole-2;5-dione, acute cholangitis, prednisolone
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