Title | Hepatoprotective effect of protein kinase inhibitor 1-(4-Cl-benzyl)-3-chloro-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione on rats' acute cholangitis |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Kuznietsova, HM, Dziubenko, NV, Lynchak, OV, Tykhoniuk, OI, Milokhov, DS, Khilya, OV, Rybalchenko, VK |
Abbreviated Key Title | Dopov. Nac. akad. nauk Ukr. |
DOI | 10.15407/dopovidi2018.05.083 |
Issue | 5 |
Section | Biology |
Pagination | 83-90 |
Date Published | 5/2018 |
Language | Ukrainian |
Abstract | The effect of protein kinase inhibitor 1-(4-Cl-benzyl)-3-chloro-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione (MI-1) on liver states of rats experienced α-naphthyl isothiocyanate-induced acute cholangitis in comparison with an tiinflammatory drug prednisolone is investigated. Both prednisolone and MI-1 attenuated cholangitis manifestations and partially restored the liver functional activity: prednisolone decreased serum transaminases acti vities, while MI-1 leveled direct and total bilirubin, which could indicate its effectiveness for correcting the investigated pathology. |
Keywords | 1-(4-Cl-benzyl)-3-chloro-4-CF3-phenylamino)-1H-pyrrole-2;5-dione, acute cholangitis, prednisolone |
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