Changes and interaction of erythropoietin and oxygen blood transport function in hypoxia of different geneses

TitleChanges and interaction of erythropoietin and oxygen blood transport function in hypoxia of different geneses
Publication TypeJournal Article
Year of Publication2018
AuthorsLanovenko, II, Gaschuk, AP, Zakcharenko, AS, Berezyuk, OM
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2018.05.091
Issue5
SectionMedicine
Pagination91-99
Date Published5/2018
LanguageUkrainian
Abstract

In experiment on rats with modeling of acute haemorrhage, the slight (compensated) damage of oxygen blood transport function (OBTF) (moderate hypoxemia, delivery O2 to tissue decrease) and erythropoietin (EPO) in blood 2–10 times increase was determined. In haemic hypoxia inducted by carbon monoxide (CO), the decompensated damage of OBTF (delivery and use O2 deficiency, acidosis) and the generation EPO absence are exposed. It is elucidated that a small hypoxic incentive can be sufficient for generation EPO to activation, but for the lack of a depression of energy metabolism in kidneys cortex.

Keywordserythropoietin, haemorrhage, hypoxia, hypoxic training, oxygen transport blood function
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