Changes and interaction of erythropoietin and oxygen blood transport function in hypoxia of different geneses

1Lanovenko, II, 1Gaschuk, AP, 1Zakcharenko, AS, 2Berezyuk, OM
1State Institution "Institute of Hematology and Blood Transfusion of the NAMS of Ukraine", Kyiv
2M. I. Pirogov Vinnytsia National Medical University
Dopov. Nac. akad. nauk Ukr. 2018, 5:91-99
https://doi.org/10.15407/dopovidi2018.05.091
Section: Medicine
Language: Ukrainian
Abstract: 

In experiment on rats with modeling of acute haemorrhage, the slight (compensated) damage of oxygen blood transport function (OBTF) (moderate hypoxemia, delivery O2 to tissue decrease) and erythropoietin (EPO) in blood 2–10 times increase was determined. In haemic hypoxia inducted by carbon monoxide (CO), the decompensated damage of OBTF (delivery and use O2 deficiency, acidosis) and the generation EPO absence are exposed. It is elucidated that a small hypoxic incentive can be sufficient for generation EPO to activation, but for the lack of a depression of energy metabolism in kidneys cortex.

Keywords: erythropoietin, haemorrhage, hypoxia, hypoxic training, oxygen transport blood function
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