Molecular profiling of prostate tumors

Gerashchenko, GV, Rynditch, AV, Kashuba, VI
Dopov. Nac. akad. nauk Ukr. 2018, 6:113-119
Section: Biology
Language: Ukrainian
Abstract: 

We have detected the relative gene expression levels (RE) of 56 genes in prostate adenocarcinomas (T), paired conventionally normal tissues (N), and adenomas (A). We have found 30 differential expressed genes in T compa red with A. Among them, there were cancer-related and prostate specific genes (AR, KRT18, MMP9, PTEN, TMPRSS2: ERG, VIM, ESR1, GCR, PDL1, PRLR, SRD5A2, VDR), 3 genes of lncRNA (PCA3, SCHLAP1, HOTAIR), several genes characterizing the state of a tumor microenvironment (fibroblasts, lymphocytes, macrophages) (THY1, CXCL12, CXCL14, CTGF, HIF1A, FAP, IFNB1, CTLA4, IL1RL1, IL1R1, CD163, CCR4, CCL17, CCL22, NOS2A). It is found that 29 of 56 genes have significant RE correlations in T with clinical and pa thological characteristics (Gleason score, stage, PSA level, age). The obtained results are the basis for the prostate tumors molecular profiling.

Keywords: prostate tumors, relative gene expression, tumor microenvironment, tumor molecular characteristics
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