Influence of oligoribonucleotides-D-mannitol complexes on the expression of genes under acute thioacetamide-induced hepatotoxicity

Marchyshak, TV, Yakovenko, TG, 1Tkachuk, ZYu.
1Institute of Molecular Biology and Genetics of the NAS of Ukraine, Kyiv
Dopov. Nac. akad. nauk Ukr. 2018, 7:96-102
https://doi.org/10.15407/dopovidi2018.07.096
Section: Biology
Language: Ukrainian
Abstract: 

The effect of oligoribonucleotides-D-mannitol complexes on the expression of IL-6, TNF-α, TGF-β1, and COL1A1 mRNA genes under acute hepatotoxicity has been investigated. It is shown that the administration of ORNs—D-M complexes results in the downregulation of genes encoding pro-inflammatory cytokines, including the tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6), profibrogenic cytokine TGF-β1, as well as the predominant protein of hepatic extracellular matrix — collagen I (COL1A1). The obtained results indicate that ORN—D-M complexes can modulate the expression of pro-inflammatory and profibrogenic genes involved in the development of the pathological process.

Keywords: expression of mRNA genes, ORN—D-M complexes, thioacetamide-induced hepatotoxicity
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