The preparative method of synthesis of functionalized 4,5-diarylsubstituted isoxazoles

1Moskvina, VS, 1Shablykina, OV, 1Ishchenko, VV, 1Khilya, VP
1Taras Shevchenko National University of Kyiv
Dopov. Nac. akad. nauk Ukr. 2018, 8:83-90
https://doi.org/10.15407/dopovidi2018.08.083
Section: Chemistry
Language: Ukrainian
Abstract: 

Preparative methods for the synthesis of 2-(5-arylisoxazol-4-yl)benzoic acids and 2-(5-(2-hydroxyaryl)-isoxazol- 4-yl)benzoic acids have been developed. It is shown that amides of 2 ′ -deoxybenzoinecarboxylic acids are uni ver- sal starting compounds for the preparation of structurally diverse 4,5-diarylsubstituted isoxazoles.

Keywords: 2-(5-arylisoxazol-4-yl)benzoic acids, 2′-carboxamidodeoxybenzoins, 3-[2-(morpholin-4-carbonyl)phenyl]-4H- chromen-4-ones, DMFDMA, enaminoketones, heterocyclization, recyclization
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