Synthesis of new oxoimidazolidine sulfonamides with anticancer activity

Shablykin, ОV, Korn, ii, YE, 1Brovarets, VS, 2Shablykina, OV, 2Khilya, VP
1Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv
2Taras Shevchenko National University of Kyiv
Dopov. Nac. akad. nauk Ukr. 2019, 1:79-85
https://doi.org/10.15407/dopovidi2019.01.079
Section: Chemistry
Language: Ukrainian
Abstract: 

By the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate, (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacting easily with the excess of an aliphatic amine to form new N-substituted (Z)-N’-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamides is obtained. According to the National Cancer Institute (USA) examinations, two of the six synthesized amides showed a high anticancer activity.

Keywords: anticancer activity, heterocyclization, N-substituted (Z)-N’-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamides
References: 

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