Phosphorylation of PRAS40 in leukocytes of patients with cancer and diabetes

Vatseba, TS
1Sokolova, LK
1Pushkarev, VV
1Kovzun, OI
1Pushkarev, VM
1Tronko, MD
1V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kyiv
Dopov. Nac. akad. nauk Ukr. 2019, 5:102-107
https://doi.org/10.15407/dopovidi2019.05.102
Section: Medicine
Language: Ukrainian
Abstract: 

We have studied the activity of mTORC1 (mammalian target of rapamycin complex 1) in leukocytes of patients with cancer and diabetes by immuno-enzyme analysis. It has been shown that, in the leukocytes of patients with cancer and type 2 diabetes, the phosphorylation of the mTORC1 inhibitor — PRAS40 (proline-rich substrate 40kDa) increases, which indicates the activation of kinase, which plays an important role in the formation of the insulin resistance and tumor progression. However, in patients with cancer and diabetes, the phosphorylation of PRAS40 and, accordingly, the activity of mTORC1 are significantly reduced as compared with the control. The mechanisms of mTORC1 activation and its significance for cancer and diabetes are discussed.

Keywords: cancer, mTORC1, PRAS40, type 2 diabetes
References: 

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