Phosphorylation of PRAS40 in leukocytes of patients with cancer and diabetes

TitlePhosphorylation of PRAS40 in leukocytes of patients with cancer and diabetes
Publication TypeJournal Article
Year of Publication2019
AuthorsVatseba, TS, Sokolova, LK, Pushkarev, VV, Kovzun, OI, Pushkarev, VM, Tronko, MD
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
Date Published05/2019

We have studied the activity of mTORC1 (mammalian target of rapamycin complex 1) in leukocytes of patients with cancer and diabetes by immuno-enzyme analysis. It has been shown that, in the leukocytes of patients with cancer and type 2 diabetes, the phosphorylation of the mTORC1 inhibitor — PRAS40 (proline-rich substrate 40kDa) increases, which indicates the activation of kinase, which plays an important role in the formation of the insulin resistance and tumor progression. However, in patients with cancer and diabetes, the phosphorylation of PRAS40 and, accordingly, the activity of mTORC1 are significantly reduced as compared with the control. The mechanisms of mTORC1 activation and its significance for cancer and diabetes are discussed.

Keywordscancer, mTORC1, PRAS40, type 2 diabetes

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