8-(Methyl sulfo nyl)-2,6-dihydroimidazo[1,2-c]pyrimidine-5- (3H)-ones — new heterocyclic derivatives of sulfones with antiviral activity

Solomyannyi, RM
1Brovarets, VS
2Shablykina, OV
2Moskvina, VS
2Khilya, VP
1Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv
2Taras Shevchenko National University of Kyiv
Dopov. Nac. akad. nauk Ukr. 2019, 5:75-81
https://doi.org/10.15407/dopovidi2019.05.075
Section: Chemistry
Language: Ukrainian
Abstract: 

By the interaction of 3-(R-amino)-2-(methylsulfonyl)acrylonitrile and 1-isocyanate-2-chloroethane, new sulfonе analogues of cytosine, 8-(methylsulfonyl)-6-R-2,6-dihydroimidazo[1,2-c]pyrimidine-5(3H)-ones, are synthesized. The antiviral activity of 8-(methylsulfonyl)-6-benzyl-2,6-dihydroimidazo[1,2-c]pyrimidine-5(3H)-one has been proven.

Keywords: 2-c]pyrimidine- 5(3H)-one, 3-amino-2-(methylsulfonyl)acrylonitrile, 6-dihydroimidazo[1, 8-(methylsulfonyl)-2, antiviral activity, heterocyclylization
References: 

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