Aspects of the creation of neuroprotective antiinflammatory drugs

1Chekman, IS
Belenichev, IF
Syrovaja, AO
Gorchakova, NA
Buhtijarova, NV
Ryzhenko, VP
2Levashova, OL
Chalenko, NN
1O.O. Bogomolets National Medical University, Kyiv
2Kharkiv National Medical University
Dopov. Nac. akad. nauk Ukr. 2019, 9:88-98
https://doi.org/10.15407/dopovidi2019.09.088
Section: Biochemistry
Language: Russian
Abstract: 

The chemical, physiological, and pharmacological aspects of creation of neuroprotective antiinflammatory drugs are considered. It is stated the expediency of the creation of neuroprotective compounds among the 1,2,4- tri azol derivatives and antiinflammatory compounds as the coxibes derivatives. During the synthesis of new compounds, computer programs, quantum-chemical investigations, and virtual screening have been used to determine antioxidant properties.

Keywords: antiinflammatory antioxidant properties, computer programs, neuroprotective, quantum- chemical investigations, virtual screening
References: 

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