Gadolinium orthovanadate nanoparticles increase survival of old rats

Nikitchenko, YV
Klochkov, VK
Kavok, NS
Karpenko, NA
Sedyh, OO
Bozhkov, AI
Malyukin, YV
Semynozhenko, VP
Dopov. Nac. akad. nauk Ukr. 2020, 2:29-36
https://doi.org/10.15407/dopovidi2020.02.029
Section: Materials Science
Language: Russian
Abstract: 

The effect of europium-activated gadolinium orthovanadate nanoparticles (GdVO4 : Eu3+ NPs, 8x25 nm) on the survival, thyroxine concentration, body temperature, and prooxidant-antioxidant balance in liver and blood of aging rats was studied. It was found that the application of GdVO4 : Eu3+ NPs with drinking water (0.25— 0.3 mg/kg of weight per day) from 22-month-old age leads to a significant increase in the survival. The survival medians of control and experimental rats were 900 and 1010 days. A decrease in the rectal temperature and the preservation of the thyroxine concentration in the blood at the level of younger animals were noted: 50.1 ± 1.9 nmol / L vs. 41.4 ± 3.3 nmol / L in the control (p < 0.05). The normalization of the prooxidant-antioxidant balance in liver and blood of aging animals has been established. So, in 33 month old rats treated with nanoparticles, the level of lipid hydroperoxides in serum and liver mitochondrial fraction decreased and did not differ from the indices of 12 month old control rats. Apparently, this effect was facilitated by an increase in the activity of the glutathione peroxidase antioxidant system and glutathione reductase activity in the postmitochondrial fraction of liver to the level of 12 month old rats under the influence of nanoparticles. The data obtained indicate the pro mise of GdVO4Eu3+ NPs for the development of geroprotective drugs that increase the life expectancy of an aging organism.

Keywords: body temperature, GdVO4 : Eu3+, nanoparticles, prooxidant-antioxidant balance., survival of old rats, thyroxinе
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