Application of analogs of gonadotropinum-releasing hormone to girls with spontaneous sexual development, who suffer from the patients with Shereshevskii–Terner syndrome

TitleApplication of analogs of gonadotropinum-releasing hormone to girls with spontaneous sexual development, who suffer from the patients with Shereshevskii–Terner syndrome
Publication TypeJournal Article
Year of Publication2014
AuthorsSprynchuk, NA
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2014.10.175
Issue10
SectionMedicine
Pagination175-180
Date Published10/2014
LanguageUkrainian
Abstract

This article presents the results of research on the assessment and the treatment of 70 children with Turner's syndrome. 38 girls had classic version karyotype — 45, XO and 32 children — mosaic forms. At 8 children from them, sexual development began without medicamental intervention. It is proved that the use of analogues of gonadotropin-releasing hormone in combination with growth hormone significantly improves the ultimate height of patients with independent activation of ovaries.

Keywordsgonadotropinum-releasing hormone, sexual development, Shereshevskii–Terner syndrome
References: 

1. Dedov I. I., Peterkova V. A., Volevodz N. N. Shereshevskoho Syndrome Turner (pathogenesis, Clinic, Diagnosis, Treatment): Methodical recommendations, Moscow: GUENTS RAMN, 2009 (in Russian).
2. Bondy C. A. J. Clin. Endocrin. Metab., 2006, 10: 1310–1374.
3. Saenger P. N. Engl. J. Med., 1996, 335: 1749–1754. https://doi.org/10.1056/NEJM199612053352307
4. Sybert V. P., McCauley E. N. Engl. J. Med., 2004, 351: 1227–1238. https://doi.org/10.1056/NEJMra030360
5. Dedov I. I., Semicheva T. V., Peterkova V. A. Sexual development of children: norm and pathology, Moscow: Kolor It Studio, 2002 (in Russian).
6. Ranke M. B. et al. Acta Paediatr. Scand, 1988, 343: 22–30.
7. Donaldson M. D. C. et al. Arch. Dis. Child., 2006, 91: 513–520. https://doi.org/10.1136/adc.2003.035907
8. Sas T. C., de Muinck Keizer-Schrama S. M. Horm. Res., 2001,  56, No 1: 38–43.
9. Gravholt C. H. Expert. Opin. Pharmacother, 2001, 10, No 2: 1633–1647. https://doi.org/10.1517/14656566.2.10.1633
10. Hanton L. et al. J. Womens Health, 2003, 12: 971–977. https://doi.org/10.1089/154099903322643893
11. Tsuchiya K. et al. Am. J. Hum. Genet., 1995, 57: 1400–1407.
12. Gravhholt C. H. Europ. J. Endocrinol, 2004, 151: 657–687. https://doi.org/10.1530/eje.0.1510657