Comparison of the effectivenesses of a new targeted compound maleimide derivative and cytostatic 5-fluorouracil in chemo-induced colon cancer in rats

TitleComparison of the effectivenesses of a new targeted compound maleimide derivative and cytostatic 5-fluorouracil in chemo-induced colon cancer in rats
Publication TypeJournal Article
Year of Publication2014
AuthorsBabyta, OM, Lynchak, OV, Rybalchenko, VK
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2014.02.142
Issue2
SectionBiology
Pagination142-145
Date Published2/2014
LanguageUkrainian
Abstract

The maleimide derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione (MI-1) is quite efficient in comparison with 5-fluorouracil in rat chemo-induced colon carcinogenesis. MI-1 is a promising compound for the further research and can become a basis for developing new targeted anticancer drugs.

Keywordschemo-induced cancer, colon of rats, effectivenesses, targeted compound maleimide
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