Development and researches of a biological active polymeric material with immobilized Vincristine

TitleDevelopment and researches of a biological active polymeric material with immobilized Vincristine
Publication TypeJournal Article
Year of Publication2014
AuthorsDemchenko, IB, Kiseleva, TA, Narazhajko, LPh., Galatenko, NA
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
Date Published5/2014

New composite materials on the basis of branched out polyether glycol urethane (PEGU) with physically immobilized antineoplastic preparation Vincristine are developed, and their efficiencies are investigated. The method of IR-spectroscopy established the influence of Vincristine on the structure of the received composites. By results of physical-mechanical tests, the introduction of Vincristine into the structure of PEGU doesn't lead to a deterioration of its physical-mechanical properties, and its high elasticity and tensile strength are conserved. The obtained film material can be recommended for the passing of further medical-biological tests as a material for the production of covers of hydrophilic implants.

Keywordsbiological active, immobilized Vincristine, polymer

1. Kebuladze I. M. Ukr. J. Non-invas. and Endoscop. Surg., 2001, No. 4: 7–9.
2. Patel V., Amiji M. Pharmaceutical Research., 1996, 13, No. 4: 588–593.
3. Jiang B., Hu L., Gao Ch. et al. Acta Biomater., 2006, 2: 9–18.
4. Marie E., Landfester K., Antonietti M. Biomacromolecules, 2002, No. 3: 475–481.
5. Markoishvili K., Tsitlanadze G., Katsarava R. et al. Int. J. Dermatol., 2002, 41: 453–458.
6. Acosta N., Aranaz I., Peniche C. et al. Macromolec. Bioscience, 2003, 3, No. 10: 546–551.
7. Pitarresi G., Cavallaro G., Giammona G. et al. Biomaterials, 2002, 23: 407 – 412.
8. Park J. H., Kwon S., Lee M. et al. Biomaterials, 2006, 27: 119–126.
9. Collis N., Coleman D., Foo I. T. N. et al. Plastic and Reconstructive Surgery, 2000, 106: 786–791.
10. Niessen F. B., Spauwen P. H. M., Robinson P. H. et al. Plastic and Reconstructive Surgery, 1998, 6, No. 102: 1962. – 1972.
11. Gasperoni C., Algarello M., Gardani G. Ann. Plastic Surgery, 1992, 29: 303–308.
12. Galatenko N. A., Baraboi V. A., Tolstopiatov B. A et al. Eksperiment. onkologiia, 1991, 13, No. 2: 59–62 (in Russian).
13. Rozhnova R. A. Polimer. zhurn., 2006, 28, No. 4: 297–302 (in Ukrainian).
14. Saunders J., Frisch K. Chemistry of polyurethanes. Moscow: Khimiia, 1968 (in Russian).