Title | Development and researches of a biological active polymeric material with immobilized Vincristine |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Demchenko, IB, Kiseleva, TA, Narazhajko, LPh., Galatenko, NA |
Abbreviated Key Title | Dopov. Nac. akad. nauk Ukr. |
DOI | 10.15407/dopovidi2014.05.121 |
Issue | 5 |
Section | Chemistry |
Pagination | 121-127 |
Date Published | 5/2014 |
Language | Ukrainian |
Abstract | New composite materials on the basis of branched out polyether glycol urethane (PEGU) with physically immobilized antineoplastic preparation Vincristine are developed, and their efficiencies are investigated. The method of IR-spectroscopy established the influence of Vincristine on the structure of the received composites. By results of physical-mechanical tests, the introduction of Vincristine into the structure of PEGU doesn't lead to a deterioration of its physical-mechanical properties, and its high elasticity and tensile strength are conserved. The obtained film material can be recommended for the passing of further medical-biological tests as a material for the production of covers of hydrophilic implants. |
Keywords | biological active, immobilized Vincristine, polymer |
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