Effects of paclitaxel and nuclear factor NF-κB inhibitor in thyroid cancer tumors in vivo

TitleEffects of paclitaxel and nuclear factor NF-κB inhibitor in thyroid cancer tumors in vivo
Publication TypeJournal Article
Year of Publication2014
AuthorsPushkarev, VM, Kovzun, OI, Pushkarev, VV, Tronko, MD
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
Date Published5/2014

Nuclear factor kappa B (NF-κB) inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) enhances the therapeutic effect of paclitaxel on tumors formed by the xenotransplantation of anaplastic thyroid carcinoma FRO cells. In animals treated with paclitaxel and NF-κB inhibitor, a reduction in the tumor volume was observed, which is significantly different from the effects of each of the compounds in particular. Thus, the combined use of paclitaxel and NF-κB inhibitor is a promising strategy for further preclinical studies for developing the new chemotherapeutic approaches for the anaplastic thyroid cancer treatment.

Keywordsinhibitor, nuclear factor, paclitaxel, thyroid cancer tumors

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