Effect of the complex of C60 fullerene with doxorubicin on tumor cells in vitro and in vivo

TitleEffect of the complex of C60 fullerene with doxorubicin on tumor cells in vitro and in vivo
Publication TypeJournal Article
Year of Publication2014
AuthorsPrylutska, SV
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2014.06.146
Issue6
SectionBiochemistry
Pagination146-150
Date Published6/2014
LanguageUkrainian
Abstract

A technological scheme for preparing a stable aqueous solution of C60 fullerene with an antibiotic doxorubicin (Dox) of the anthracycline row is proposed. The toxic effect of the C60+Dox complex on cells of Ehrlich ascites carcinoma, leukemia L1210, and Lewis lung carcinoma is demonstrated. Its antitumor effect on Lewis lung carcinoma in vivo was also shown. Thus, a high efficiency of the C60+Dox complex in the anticancer therapy is postulated.
Keywordscomplex of C60 fullerene, doxorubicin, tumor cells
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