Title | Sensitivity of Lewis Lung Carcinoma (LLC) and LLC/R9 cells to cytotoxic action exerted by murine natural killer cells and macrophages of C57BL/6 mice in vitro |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Fedorchuk, OG, Lyon, AD, Yakshibaeva, Yu.R, Gorbik, GV, Pyaskovskaya, ON |
Abbreviated Key Title | Dopov. Nac. akad. nauk Ukr. |
DOI | 10.15407/dopovidi2014.06.167 |
Issue | 6 |
Section | Medicine |
Pagination | 167-172 |
Date Published | 6/2014 |
Language | Ukrainian |
Abstract | The comparative investigation of the sensitivity of primary LLC and drug resistant LLC/R9 cells to natural killer cells and macrophages of C57BL/6 intact mice is performed in vitro. It is shown that the forming of a resistance to cisplatin by LLC cells is accompanied by an increase of their sensitivity to the cytotoxic action of natural killer cells and a decrease of the susceptibility to the cytolytic activity of macrophages. High LLC/R9 cell sensitivity to the cytotoxic action of natural killer cells possibly was caused by a diminished expression of MHC class I molecules. Decreased sensitivity of resistant cells to the cytolysis by nonsensitized macrophages was associated with a high ability to undergo autophagy. |
Keywords | killer cells, Lewis lung carcinoma, macrophages of mice |
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