Comparison of the impacts of cytostatic compounds of maleimide derivative and 5-fluorouracil on the morphofunctional status of rat's liver under conditions of colon carcinogenesis

TitleComparison of the impacts of cytostatic compounds of maleimide derivative and 5-fluorouracil on the morphofunctional status of rat's liver under conditions of colon carcinogenesis
Publication TypeJournal Article
Year of Publication2014
AuthorsDanylov, MO, Ostrovska, GV, Rybalchenko, VK
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2014.07.140
Issue7
SectionBiology
Pagination140-144
Date Published7/2014
LanguageUkrainian
Abstract

The maleimide derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione causes no destructive effect on the histological structure in rat's liver after the 7 week administation. It also has a partial protective effect under the conditions of colon carcinogenesis, induced by 1,2-dimethylhydrazine, unlike traditional anticancer drug 5-fluorouracil, which showed hepatotoxic effects.

Keywords5-fluorouracil, colon carcinogenesis, maleimide, rat's liver
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