Synthesis of new chloroaryl-containing sulfonylamides of isoxazole series via ring-closing metathesis

TitleSynthesis of new chloroaryl-containing sulfonylamides of isoxazole series via ring-closing metathesis
Publication TypeJournal Article
Year of Publication2015
AuthorsPavliuk, OV, Bezugly, Yu.V, Holovatiuk, VM, Kashkovsky, VI
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2015.10.064
Issue10
SectionChemistry
Pagination64-71
Date Published10/2015
LanguageUkrainian
Abstract

A number of new chloroaryl-containing sulfonyl chlorides of isoxazole series that have been converted into the corresponding diallyl sulfonamides was synthesized by means of oxidative chlorination. The ring-closing metathesis reaction of obtained sulfonamides was conducted with the help of the ruthenium carbene catalyst. A number of new, potentially bioactive, pyroline-containing choroarylsubstituted sulfonylamide derivatives of isoxazole was synthesized.
Keywordsisoxazole, metathesis, ruthenium carbene catalyst, sulfonamide, sulfonylchloride
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