Interaction of antitumor cytokine EMAP II with gamma-cyclodextrin

TitleInteraction of antitumor cytokine EMAP II with gamma-cyclodextrin
Publication TypeJournal Article
Year of Publication2015
AuthorsMalyna, AE, Nesterenko, EV, Dragan, AI, Kornelyuk, OI
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
Date Published10/2015

The interaction of antitumor cytokine EMAP II with gamma-cyclodextrin (γ-CD) is investigated. The exposure of aromatic amino acid residues in the structure of the recombinant cytokine EMAP II has analyzed. It is found that γ-CD binds specifically with EMAP II, the most likely binding site being partially exposed residue Trp128 localized in a recess on the surface of EMAP II along with the functionally important lysine-rich cluster.

Keywordscomplex binding, EMAP II, fluorescence, gamma-cyclodextrin
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