Title | Interaction of antitumor cytokine EMAP II with gamma-cyclodextrin |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Malyna, AE, Nesterenko, EV, Dragan, AI, Kornelyuk, OI |
Abbreviated Key Title | Dopov. Nac. akad. nauk Ukr. |
DOI | 10.15407/dopovidi2015.10.072 |
Issue | 10 |
Section | Biochemistry |
Pagination | 72-76 |
Date Published | 10/2015 |
Language | Ukrainian |
Abstract | The interaction of antitumor cytokine EMAP II with gamma-cyclodextrin (γ-CD) is investigated. The exposure of aromatic amino acid residues in the structure of the recombinant cytokine EMAP II has analyzed. It is found that γ-CD binds specifically with EMAP II, the most likely binding site being partially exposed residue Trp128 localized in a recess on the surface of EMAP II along with the functionally important lysine-rich cluster. |
Keywords | complex binding, EMAP II, fluorescence, gamma-cyclodextrin |
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