Formation of the chromosomal and microsatellite instabilities in blood cells of cancer patients under the combined exposure in vitro to ionizing radiation and co-mutagens

TitleFormation of the chromosomal and microsatellite instabilities in blood cells of cancer patients under the combined exposure in vitro to ionizing radiation and co-mutagens
Publication TypeJournal Article
Year of Publication2015
AuthorsDomina, EA, Ivankova, VS, Pylypchuk, OP, Zelena, LB
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2015.05.165
Issue5
SectionMedicine
Pagination165-172
Date Published5/2015
LanguageRussian
Abstract

This work presents the first studies of the quantitative and qualitative patterns of genome instability formation in irradiated somatic cells of cancer patients under the influence of a co-mutagen ascorbic acid. Depending on the drug concentration, the co-mutagenic effects were revealed as an increased frequency of chromosomal aberrations by 1.4–1.7 times due to the repair system repression. The obtained results should be taken into account in the radiation oncology for the control over comutagenic drug prescriptions to the patient to prevent the development of secondary tumors.
Keywordsascorbic acid, co-mutagenic effects, irradiation, microsatellite instability, peripheral blood lymphocytes of cancer patients, radiation-induced chromosomal aberrations
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