Regularities of the formation of comutagenesis in irradiated human somatic cells

TitleRegularities of the formation of comutagenesis in irradiated human somatic cells
Publication TypeJournal Article
Year of Publication2015
AuthorsPylypchuk, OP, Domina, EA
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2015.08.131
Issue8
SectionBiology
Pagination131-136
Date Published8/2015
LanguageUkrainian
Abstract

The pattern (regularity) of co-mutagenic effects formation in healthy individuals' irradiated cells (T-lymphocytes) under verapamil and ascorbic acid treatment is studied. It is determined that the additional action of the investigated drugs in concentrations greater than the therapeutic one potentiate the effects of low doses of ionizing radiation by 1.5 times. Ascorbic acid and verapamil show co-mutagenic effects under high-dose irradiation (2.0 Gy), increasing the chromosomal aberration level by 1.4 times, regardless of the concentration of drugs.
Keywordsascorbic acid, chromosomal aberrations, comutagen, ionizing radiation, peripheral blood lymphocytes, verapamil
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