Solid-phase microextraction of aliphatic aldehydes C5–C8 and gas chromatographic determination for lung cancer diagnosis

TitleSolid-phase microextraction of aliphatic aldehydes C5–C8 and gas chromatographic determination for lung cancer diagnosis
Publication TypeJournal Article
Year of Publication2016
AuthorsZakharkiv, IB, Zui, MF
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2016.08.085
Issue8
SectionChemistry
Pagination85-91
Date Published8/2016
LanguageUkrainian
Abstract

A headspace solid-phase microextraction procedure followed by gas chromatography with flame ionization detection has been developed for the preconcentration and the determination of aliphatic aldehydes C5−C8 in the form of its o-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine derivatives in water samples. Commercial polydimethylsiloxane-divinylbenzene fiber was used as a preconcentration coating. Under optimal conditions, the enrichment factors of analytes were in the range 7280–8650, and the limits of detection were 0.016–0.020 μM/L.

Keywordsaliphatic aldehydes, derivatization, gas chromatography, o-(2;3;4;5;6-pentafluorobenzyl) hydroxylamine hydrochloride, solid phase microextraction
References: 
  1. Fuchs P., Loeseken C., Schubert J., Miekisch W. Int. J. Cancer, 2009, 126: 2663–2670.
  2. Phillips M., Gleeson K., Hughes M., Greenberg J., Cataneo R., Baker L., McVay P. Lancet, 1999, 353: 1930–1933. DOI: https://doi.org/10.1016/S0140-6736(98)07552-7
  3. Deng C., Zhang X., Li N. J. Chromatogr. B, 2004, 808: 269–277. DOI: https://doi.org/10.1016/j.jchromb.2004.05.015, PMid:15261821
  4. Hakim M., Broza Y., Barash O., Peled N., Phillips M., Amann A., Haick H. Chem. Rev., 2012, 112, No 11: 5949–5966. DOI: https://doi.org/10.1021/cr300174a, PMid:22991938
  5. Xu H., Lv L., Hu S., Song D. J. Chromatogr. A, 2010, 1217: 2371–2375. DOI: https://doi.org/10.1016/j.chroma.2009.09.068, PMid:19819460
  6. Cancilla D., Que Hee S. J. Chromatogr., 1992, 627: 1–16. DOI: https://doi.org/10.1016/0021-9673(92)87181-7
  7. Method 556: Determination of carbonyl compounds in drinking water by pentafluorobenzylhydroxylamine derivatization and capillary gas chromatography with electron capture detection, National Exposure Research Laboratory. Office of Research and Development, Cincinnatti, Ohio 45268. 1998, 1–37.
  8. Zaitsev V. N., Zui M. F. J. Anal., Chem., 2014, 69, No 8: 787–800 (in Russian). DOI: https://doi.org/10.1134/S1061934814080139