Evaluation of the effect of professional irradiation on cytogenetic parameters of peripheral blood lymphocytes

TitleEvaluation of the effect of professional irradiation on cytogenetic parameters of peripheral blood lymphocytes
Publication TypeJournal Article
Year of Publication2018
AuthorsDomina, EA
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
Date Published10/2018

The cytogenetic examination of radiologists with different work experiences in the field of ioni zing radiation has been performed. Preliminary data indicate that radiologists with over 1.5 years of experience exhibit, ~ in 70 % of cases, an increased level of chromosomal aberrations, including dicentrics and translocations (from 0.5 to 6.0 / 100 metaphases). This indicates a radiation load on the genome of the examined professionals. The radiomitigators inosine and thymalin reduce the frequency of radiation-induced aberrations of chromosomes upon the irradiation in small doses to the values of the average population spontaneous level.

Keywordsblood lymphocytes, carcinogenic risk, genome instability, professional exposure, ra diomitigators
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