Water bounding peculiarities in SiO2/laevomycetin and SiO2/laevomycetin/AM1 composite systems

TitleWater bounding peculiarities in SiO2/laevomycetin and SiO2/laevomycetin/AM1 composite systems
Publication TypeJournal Article
Year of Publication2018
AuthorsKrupskaya, TV, Rugal, AO, Turov, VV
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
Date Published10/2018

Water bounding in a silicabased system containing adsorbed laevomycetin:(SiO2/ laevomycetin) and SiO2/ laevomycetin with addition AM1(methylsilica) are studied by lowtemperature 1H NMR spectroscopy. It is re vealed that the laevomycetin immobilization leads to a certain extent of hydrophilic properties and the amount of bounded water. It is shown that the replacement of air by liquid media (CDCl3) initiates increasing the interfacial energy up to 30 %. For the same time, the addition of AM1 into the mentioned system led to the quadruplication of the interfacial energy. Consequently, this is a promising way to use such systems for the creation of retarded drugs.

Keywordsinterfacial energy, laevomycetin, lowtemperature 1H NMR spectroscopy, methylsilica, nanosilica
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