Laevomycetin release rate control in a silica-based composite system

TitleLaevomycetin release rate control in a silica-based composite system
Publication TypeJournal Article
Year of Publication2018
AuthorsRugal, AO, Krupskaya, TV, Turov, VV
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2018.07.077
Issue7
SectionChemistry
Pagination77-81
Date Published7/2018
LanguageRussian
Abstract

A composite system based on silica and laevomycetin is obtained, and the capability to control the antibiotic release rate by changing the silica surface coating with laevomycetin is shown. It is revealed that the method of impregnation is optimal due to its facility to regulate the desorption rate on a slow stage.
Keywordscomposite system, desorption, impregnation, laevomycetin, nanosilica
References: 
  1. Chuiko, A. A. (Ed.). (2003). Medical chemistry and clinical application of silica dioxide. Kiev: Naukova Dumka (in Russian).
  2. Chekman, I. S., Gorchakova, N. O., Kazak, L. I., Belenichev, I. F. & Bobiryov, V. M. (Eds). (2016). Pharmacology. Vinnica: Nova Kniga (in Ukrainian).
  3. Hlusov, I. V., Chuchalin, V. S., Horuzhaja, T. G. (2008). Fundamentals of creation and drug delivery systems functionalization and operation. Tomsk: Izd-vo Tomskogo Politechn. un-ta (in Russian).
  4. Zhang, S., Chu, Z., Yin, C., Zhang, C., Lin, G. & Li, Q. (2013). Controllable drug release and simultaneously carrier decomposition of SiO2-drug composite nanoparticles. J. Am. Chem. Soc., 135, No. 15, pp. 5709-5716. doi: https://doi.org/10.1021/ja3123015
  5. Pat. 105151 UA. IPC BO1J 2/10 (2006/01), Method for compacting nanosilica, Krupska, T.V., Turov, V.V., Barvinchenko, V.M., Filatova, K.O., Suvorova, L.A., Kartel, M.T., Publ. 10.03.2016 (in Ukrainian).
  6. Krupskaya, T. V., Turov, V. V., Barvinchenko, V. N., Filatova, K. O., Suvorova, L. A., Iraci, G. & Kartel, M. T. (2018). Influence of the “wetting-drying” compaction on the adsorption characteristics of nanosilica A-300. Ads. Sci. & Tech., 36, Iss. 1-2, pp. 300-310. doi: https://doi.org/10.1177/0263617417691768
  7. Khodarchenko, G. B., Tikhonov, O. I., Grytsan, A. D. & Vishnevskaya, L. I. (2003). The study of laevomycetini adsorption by the enterosorbent of the silica origin silics. Visn. Pharmacii, 36, Iss. 4. pp. 68-70 (in Ukrainian).
  8. Egorov, N. S. (2004). Fundamentals of antibiotics theory. Moscow: Izd-vo Mosk. un-ta (in Russian).
  9. Mashkovsky, M. D. (2012). Drugs. Moscow: Novaja Volna (in Russian).