The process of release of the active substance from a model composite system based on black tea and silica

TitleThe process of release of the active substance from a model composite system based on black tea and silica
Publication TypeJournal Article
Year of Publication2020
AuthorsKlymenko, NYu., Krupska, TV, Turov, VV
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
Date Published1/2020

Composite systems based on hydrophilic silica and a mixture of hydrophilic and hydrophobic silica with different bulk densities (45, 175, 300 g/l) and black tea are investigated. It is found that, with increasing the tea con centration, the optical density of a solution increases linearly. It is shown that tea components can be adsorbed on hydrophilic silica in an amount not exceeding 0.002 g/g. It is determined that the formed composite systems have two stages of release of active substances (fast and slow ones), which conditionates their prolon ged action. Due to the interaction of silica particles and the cellulosic matrix of medicinal plants, it is possible to control and to widely regulate the desorption process, by changing the physicochemical parameters of the desorption process and the bulk density of composite systems and by using hydrophobic silica additives. The effect of readsorp tion of biologically active substances in interparticle gaps of the composite system is found. It has been sug gested that this effect can be used to create composite systems of a new generation suitable for the treatment of various diseases.

Keywordsblack tea, composite systems, desorption, silica, UV spectroscopy

1. Ruban, O. A., Gritsenko, V. I. & Zaporozhskaya, S. M. (2016). Drug delivery systems. Kharkiv: NFaU (in Ukrainian).
2. Chuyko, A. A. (Ed.). (2003). Medical chemistry and clinical use of silicon dioxide. Kyiv: Naukova Dumka (in Russian).
3. Turov, V. V., Krupska, T. V., Golovan, À. P., Àndriyko, L. S. & Êartel, Ì. Ò. (2017). Water binding in composite systems based on milled medicinal plants and nanosilica. Biotechnologia Acta., 10, No. 2, pp. 4056. Doi:
4. Turov, V. V., Krupska, Ò. V., Golovan, A. P., Àndriyko, L. S. & Êartel, Ì. Ò. (2017). Longacting composite systems based on powdered medicinal plants and nanosilica. Nauka innov., 13, No. 2. P. 59-67 (in Ukrainian). Doi:
5. Postnov, W. N., Naumysheva, Ye. B., Koroljov, D. W. & Galagudza, M. M. (2013). Nanosized carriers for drug delivery applications. Biotekhnosfera, No. 6, pp. 16-27 (in Russian).
6. Krupskaya, Ò. V., Rugal, À. Î. & Òurov, V. V. (2018). Water bounding peculiarities in SiO2/laevomycetin and SiO2/laevomycetin/ÀÌ1 composite systems. Dopov. Nac. akad. nauk Ukr., No. 10, pp. 72-78 (in Russian). Doi:
7. Turov, V. V., Gun’ko, V. M., Pakhlov, E. M., Krupska, T. V., Tsapko, M. D., Charmas, B. & Kartel, M. T. (2018). Influence of hydrophobic nanosilica and hydrophobic medium on water bound in hydrophilic components of complex systems. Colloids Surf. A. Physicochem. Eng. Asp., 552, pp. 39-47. Doi:
8. Zhang, H., Qi, R. & Mine, Y. (2019). The impact of oolong and black tea polyphenols on human health. Food Biosci., 29, pp. 55-61. Doi:
9. Katiyar, S. K., Perez, A. & Mukhatar, H. (2000). Green tea polyphenol treatment to human skin prevents formation of ultraviolet light Binduced pyrimidine dimers in DNA. Clin. Cancer Res., 6, pp. 3864-3869.
10. Hussain S., Anjali, K. P., Hassan, S. T. & Dwivedi, P. B. (2018). Waste tea as a novel adsorbent: a review. Appl. Water Sci., 8, Iss. 6, 165, 16 p. Doi:
11. Krupskaya, T. V., Turov, V. V., Barvinchenko, V. M., Filatova, K. O., Suvorova, L. A., Iraci, G. & Kartel, M. T. (2018). Influence of the “wettingdrying” compaction on the adsorptive characteristics of nanosilica A300. Adsorpt. Sci. Technol., 36, Iss. 12, pp. 300-310. Doi:
12. Yugdurova, E. D., Nikolaeva, G. G., Nagaslaeva, L. A., Nikolaev, S. M. & Markaryan, A. A. (2004). Working out the method of quantative determination of the sum of phlavanoid by UVspectrophotometry in the tea “Baikalsky6”. Sib. Med. Zhurn., 45, No. 4, pp. 71-74 (in Russian).
13. Bajpai, A. K., Shukla, S. K., Bhanu, S. & Kankane, S. (2008). Responsive polymers in controlled drug delivery. Progr. Polym. Sci., 33, Iss. 11, pp. 1088-1118. Doi:
14. Turov, V. V., Gun’ko, V. M., Barvinchenko, V. N., Rugal, A. A., Turova, A. A. & Fedianina, T. V. (2009). Hydration of cellulose with the presence of quercetin and organic solvents. Chemistry, Physics and Technology of Surface, No.15, pp. 169-180 (in Russian).