|Title||Succinic acid derivatives: influence on the metabolic factors of the development of fatigue and working capacity under physical loads|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Gunina, LM, Voitenko, VL, Nosach, EV|
|Abbreviated Key Title||Dopov. Nac. akad. nauk Ukr.|
A study has been carried out on the effect of the domestic pharmacological armadin long preparation (2-ethyl- 6-methyl-3-hydroxypyridine succinate) on the physical working capacity of athletes under the maximum intensity force loads characteristic of modern sports. Since pharmacology in sports is constantly searching for non-toxic drugs of the metabolithotropic origin that would have the ability to promote physical efficiency and slow down fatigue without toxic effects on the body, we have chosen for our research a drug based on succinic acid, which is a natural metabolite of the Krebs cycle. It has been shown that the armadin long preparation, when applied on a course for three weeks, positively affects the parameters of special working capacity associated with the improvement of the oxygen-transport function of blood. The metabolic basis of this phenomenon is the inhibition of a decrease in the pH of the internal environment of the body with the subsequent development of lactate-acidosis and the ability of the armadin long drug to accelerate the processes of angiogenesis, and, accordingly, the transport of oxygen to the athlete’s working muscles. The intensity of the formation of new growth factor (VEGF). Such data substantiate the expediency of the use of succinic acid-based agents to prevent negative metabolic changes and to slow down the onset of fatigue in athletes under intense physical loads.
|Keywords||angiogenesis, lactate-acidosis, physical working capacity of athletes, power loads, vascular endothelial growth factor|
1. Barrientos, A., Fontanesi, F. & Diaz, F. (2009). Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using polarography and spectrophotometric enzyme assays. Curr. Protoc. Hum. Genet., Chapter 19, Unit 19.3. https://doi.org/10.1002/0471142905.hg1903s63
2. Soares, J.P., Silva, A.M., Oliveir, M.M., Peixoto, F., Gaivão, I. & Mota, M.P. (2015). Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes. Age (Dordr), 37, No. 3, 9799. https://doi.org/10.1007/s11357-015-9799-4
3. Pavić, M., Turčić, P. & Ljubojević, M. (2019). Forgotten partners and function regulators of inducible metallothioneins. Arh. Hig. Rada Toksikol., 70, No. 4, рр. 256-264. https://doi/10.2478/aiht-2019-70-3317
4. Lindholm, M.E. & Rundqvist, H. (2016). Skeletal muscle hypoxia-inducible factor-1 and exercise. Exp. Physiol., 101, No. 1, рр. 28-32. https://doi.org/10.1113/EP085318
5. Oleshko, V.G. (2005). Modeling the process of training and improving athletes in strength sports. Kyiv: DMP “Polimed” (in Ukrainian).
6. Kornyakova, V.V., Badtieva, V.A. & Balandin, M.Yu. (2020). Exploiting dietary supplements with antioxidant properties for enhancing physical efficiency at the state of physical fatigue in sports. Vopr. Pitaniia, 89, No. 3, pp. 86-96 (in Russian). https://doi.org/10.24411/0042-8833-2020-10032
7. Mota, M.R., Dantas, R.A.E., Oliveira-Silva, I., Sales, M.M., Sotero, R.D.C., Venâncio, P.E.M., Teixeira, J., j., Chaves, S.N. & de Lima, F.D. (2017). Effect of self-paced active recovery and passive recovery on blood lactate removal following a 200 m freestyle swimming trial. Open Access J. Sports Med., 8, pp. 155-60. https://doi.org/10.2147/OAJSM.S127948
8. Rahman, M.Q., Chuah, K.S., Macdonald, E.C.A., Trusler, J.P.M. & Ramaesh, K. (2012). The effect of pH, dilution, and temperature on the viscosity of ocular lubricants-shift in rheological parameters and potential clinical significance. Eye, 26, No. 12, рр. 1579-1584. https://doi.org/10.1038/eye.2012.211
9. Alleman, R.J., Tsang, A.M., Ryan, T.E., Patteson, D.J., McClung, J.M., Spangenburg, E.E., Shaikh, S.R., Neufer, P.D. & Brown, D.A. (2016). Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Am. J. Physiol. Heart Circ. Physiol., 310, No. 10, pp. H1360-Н1370. https://doi.org/10.1152/ajpheart.00858.2015
10. Damiano, S., Montagnaro, S., Puzio, M.V., Severino, L., Pagnini, U., Barbarino, M., Cesari, D., Giordano, A., Florio, S. & Ciarcia, R. (2018). Effects of antioxidants on apoptosis induced by dasatinib and nilotinib in K562 cells. J. Cell Biochem., 119, No. 6, рр. 4845-4854. https://doi.org/10.1002/jcb.26686
11. Meerson, F.Z. & Pshennikova, M.G. (1988). Adaptation to stressful situations and physical activity. Moscow: Meditsina (in Russian).
12. Huang, S., He, P., Xu, D., Li, J., Peng, X. & Tang, Y. (2017). Acidic stress induces apoptosis and inhibits angiogenesis in human bone marrow-derived endothelial progenitor cells. Oncol. Lett., 14, No. 5, pp. 5695-5702. https://doi.org/10.3892/ol.2017.6947