Effects of COVID-19, diabetes mellitus, and cardiovascular diseases on insulin receptor substrate-1 amount in the blood plasma of patients





Insulin receptor substrate-1, COVID-19, diabetes mellitus, cardiovascular diseases


Insulin receptor substrate (IRS) is a key adapter protein mediating effects of insulin and insulin-like growth factors (IGF) in cells. IRS-1 is a member of the insulin receptor substrate family, which is associated with tumor initiation and progression. The aim of the study is to determine the level of IRS-1 in the blood of patients (n = 81) with diabetes mellitus and COVID-19. IRS-1 was determined with enzyme-linked immunosorbent assay (ELISA) (Elabscience, USA). The measurements were performed at an optical wavelength of 450 nm. The level of IRS-1 in the blood plasma of patients with COVID-19 was much (from 3.5 to more than 6 times) higher than that in the blood of healthy people. The IRS-1 amounts in COVID-19 patients with diabetes and diabetes + CVD were significantly higher than in patients with COVID-19 without concomitant diseases. The level of IRS-1 in blood plasma may be one of the promising markers of COVID-19.


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How to Cite

Tronko, M. D., Pushkarev, V. V., Sokolova, L. K., Cherviakova, S. A., Belchina, Y. B., Kovzun, O. I., & Pushkarev, V. M. (2021). Effects of COVID-19, diabetes mellitus, and cardiovascular diseases on insulin receptor substrate-1 amount in the blood plasma of patients. Reports of the National Academy of Sciences of Ukraine, (5), 114–117. https://doi.org/10.15407/dopovidi2021.05.114