Influence of oligoribonucleotides-D-mannitol complexes on the expression of genes under acute thioacetamide-induced hepatotoxicity

TitleInfluence of oligoribonucleotides-D-mannitol complexes on the expression of genes under acute thioacetamide-induced hepatotoxicity
Publication TypeJournal Article
Year of Publication2018
AuthorsMarchyshak, TV, Yakovenko, TG, Tkachuk, ZYu.
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2018.07.096
Issue7
SectionBiology
Pagination96-102
Date Published7/2018
LanguageUkrainian
Abstract

The effect of oligoribonucleotides-D-mannitol complexes on the expression of IL-6, TNF-α, TGF-β1, and COL1A1 mRNA genes under acute hepatotoxicity has been investigated. It is shown that the administration of ORNs—D-M complexes results in the downregulation of genes encoding pro-inflammatory cytokines, including the tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6), profibrogenic cytokine TGF-β1, as well as the predominant protein of hepatic extracellular matrix — collagen I (COL1A1). The obtained results indicate that ORN—D-M complexes can modulate the expression of pro-inflammatory and profibrogenic genes involved in the development of the pathological process.
Keywordsexpression of mRNA genes, ORN—D-M complexes, thioacetamide-induced hepatotoxicity
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