Laevomycetin release rate control in a silica-based composite system

Rugal, AO, 1Krupskaya, TV, 1Turov, VV
1O. O. Chuiko Institute of Surface Chemistry of the NAS of Ukraine, Kyiv
Dopov. Nac. akad. nauk Ukr. 2018, 7:77-81
Section: Chemistry
Language: Russian

A composite system based on silica and laevomycetin is obtained, and the capability to control the antibiotic release rate by changing the silica surface coating with laevomycetin is shown. It is revealed that the method of impregnation is optimal due to its facility to regulate the desorption rate on a slow stage.

Keywords: composite system, desorption, impregnation, laevomycetin, nanosilica
  1. Chuiko, A. A. (Ed.). (2003). Medical chemistry and clinical application of silica dioxide. Kiev: Naukova Dumka (in Russian).
  2. Chekman, I. S., Gorchakova, N. O., Kazak, L. I., Belenichev, I. F. & Bobiryov, V. M. (Eds). (2016). Pharmacology. Vinnica: Nova Kniga (in Ukrainian).
  3. Hlusov, I. V., Chuchalin, V. S., Horuzhaja, T. G. (2008). Fundamentals of creation and drug delivery systems functionalization and operation. Tomsk: Izd-vo Tomskogo Politechn. un-ta (in Russian).
  4. Zhang, S., Chu, Z., Yin, C., Zhang, C., Lin, G. & Li, Q. (2013). Controllable drug release and simultaneously carrier decomposition of SiO2-drug composite nanoparticles. J. Am. Chem. Soc., 135, No. 15, pp. 5709-5716. doi:
  5. Pat. 105151 UA. IPC BO1J 2/10 (2006/01), Method for compacting nanosilica, Krupska, T.V., Turov, V.V., Barvinchenko, V.M., Filatova, K.O., Suvorova, L.A., Kartel, M.T., Publ. 10.03.2016 (in Ukrainian).
  6. Krupskaya, T. V., Turov, V. V., Barvinchenko, V. N., Filatova, K. O., Suvorova, L. A., Iraci, G. & Kartel, M. T. (2018). Influence of the “wetting-drying” compaction on the adsorption characteristics of nanosilica A-300. Ads. Sci. & Tech., 36, Iss. 1-2, pp. 300-310. doi:
  7. Khodarchenko, G. B., Tikhonov, O. I., Grytsan, A. D. & Vishnevskaya, L. I. (2003). The study of laevomycetini adsorption by the enterosorbent of the silica origin silics. Visn. Pharmacii, 36, Iss. 4. pp. 68-70 (in Ukrainian).
  8. Egorov, N. S. (2004). Fundamentals of antibiotics theory. Moscow: Izd-vo Mosk. un-ta (in Russian).
  9. Mashkovsky, M. D. (2012). Drugs. Moscow: Novaja Volna (in Russian).